IT | EN
Coordinator: Prof. Andrea Fiorillo e-mail: Questo indirizzo email è protetto dagli spambots. È necessario abilitare JavaScript per vederlo.
Doctoral School: Life Sciences
Administrative Headquarters: Department of Mental and Physical Health and Preventive Medicine
Reference for information: Dr. Carmela Maddaloni Tel. 081/18760426, email: Questo indirizzo email è protetto dagli spambots. È necessario abilitare JavaScript per vederlo.
Duration: 3 years
Scientific disciplines involved: BIO/09 - BIO/10- BIO/11 - BIO/14- BIO/16 - FIS/07 - ING-INF/06 - MED/04 - MED/06 - MED/09 - MED/12 - MED/14 - MED/18 - MED/19 - MED/21 - MED/24- MED/25 - MED/26 - MED/31 - MED/34 - MED/35 - MED/37 - MED/39
Method of admission
- Qualification assessment
- Oral Test
- English language test
- Presentation of a research project
Admission arrangements for graduate students abroad:
- Qualification assessment
- Oral Test
- English language test
- Presentation of a research project
Curricula of the Doctoral Program:
- Curriculum 1: Nephrology
- Curriculum 2: Gastroenterology/Nutrition
- Curriculum 3: Internal Medicine/Geriatrics
- Curriculum 4: Neurology
- Curriculum 5: Child Neuropsychiatry
- Curriculum 6: Psychiatry
You can submit your application for the selection for admission to PhD courses - Cycle XL, starting from 14:00 on June 03, 2024 and no later than 14:00 on July 02, 2024, go to the announcement
NOTICES/COMMUNICATIONS
- NEW: You can submit your application for the selection for admission to PhD courses - Cycle XL - starting at 2 p.m. (Italian time) on June 3, 2024 and no later than 2 p.m. (Italian time) on July 2, 2024 go to the announcement
Description of the training project
The Ph.D. program in Clinical and Experimental Medical Sciences offers a research training pathway marked by the development of interdisciplinary approaches, from preclinical to clinical sciences, and cross-sectoral, including alongside the skills of the academic sector those of the productive sector. In particular, the aggregation of SSDs from different areas and disciplines is encouraged, as well as the activation of industrial doctoral tracks with research topics consistent with the National Research Plans and the National Strategy for Intelligent Specialization. The course provides all the necessary skills to conduct cutting-edge research on the pathophysiology of somatic and mental diseases with relevant public health impact and on the development of biotechnologies and innovative treatments in medicine and surgery.
The integration of preclinical and clinical aspects in the biomedical area and the personalization of care represent central themes common to all activated curricula, consistently aggregating different disciplines and methodologies, with reference to disciplinary areas that fall within the different areas of the ERC Domain "LS-Life Sciences," including different ERC areas, in the areas between LS1 and LS7.
The result of integrating these areas are highly multidisciplinary and multi-sectoral research projects in emerging fields such as neuroscience, applied biomedical sciences, personalized and regenerative medicine.
The training program promotes a multidisciplinary approach, integrating epidemiology, genetics, anatomical pathology, molecular biology, pathophysiology, imaging, research on animal models (in vivo and ex vivo), cellular models, and digital models, for the purpose of identifying biomarkers of complex diseases for early diagnosis or course prediction, as well as the development of innovative treatments. Particular emphasis is placed on training researchers capable of meeting the challenges of innovation and digitization, i.e., capable of strategic vision on the emergence of new opportunities, which represent the future of biomedical research, such as the creation, management and use of "data repositories," the use of artificial intelligence and "machine learning" methods that are best suited to the analysis of complex and integrated data (epidemiological, clinical, omics, genetic, socio-health and environmental) or the construction of "knowledge graphs." This type of training and research intercepts many of the NRP's challenges in health, from the prevention of chronicity and multiple comorbidities to the development of innovative medical-surgical therapies and precision medicine.
In the different Curricula, the common innovative approach to research involves: 1) The identification of biomarkers useful in preclinical or early stages of disease, for the setting of individualized prevention or treatment strategies to improve patient prognosis and quality of life; 2) The use of animal and cellular models of disease for the identification of new cellular and molecular targets for the development of innovative drug treatments; 3) The use of computational techniques to create predictive and diagnostic models of different diseases or innovative "Knowledge Graphs."
The Ph.D. program encourages the active involvement of doctoral students in interdisciplinary research projects, interaction with other researchers and companies involved in biomedical research, both nationally and internationally, to create networks of research excellence and to support the career development of doctoral students
Training Objectives
The Ph.D. in Clinical and Experimental Medical Sciences aims to enhance the synergies between basic and applied research in medicine and to promote multidisciplinary activities that foster the integration of specialized expertise in accordance with a biopsychosocial approach to the prevention and treatment of complex diseases. The doctoral program aims to train highly qualified professionals capable of independently applying the most advanced methodologies of basic and clinical research from an interdisciplinary and intersectoral perspective. The aim is to provide a solid theoretical and methodological background on the main directions of biomedical research and to foster the development of highly qualified skills that, using advanced experimental methodologies, in one with state-of-the-art computer and statistical methods, enable the planning and implementation of research projects in different areas of medicine, the development of innovative diagnostic and therapeutic applications, and the transfer of knowledge to the clinical-therapeutic field according to the principles of Evidence Based Medicine. The PhD is divided into different tracks pertaining to Psychiatry, Child Neuropsychiatry, Nephrology, Neurology, Geriatrics and Gastroenterology. The training as a whole is based on the latest methodological acquisitions in biomedical research and predominantly on direct participation in research activity, guided by internationally renowned mentors and supervisors, through direct involvement of the doctoral student in the implementation of research programs at the proposing institution or at other national or international centers,
Training activities
Teaching |
Number of hours |
Years in which teaching is active |
Description |
Brain neuroimaging techniques: clinical and research applications |
4 |
first year |
Intensive 4-hour mini-course in which the most innovative structural and functional neuroimaging techniques and their clinical and research applications in neurology and psychiatry will be explained. In particular, the following will be covered: 1) the applications of advanced neuroimaging techniques to the study of major neurological disorders in relation to phenotype and stage of disease; 2) the study of the neurofunctional correlates of the different domains of severe mental disorders also in relation to alterations in brain connectivity. |
Medical statistics-guide to setting up and interpreting Network Analysis |
4 |
first year |
Intensive 4-hour mini-course in which the basics will be provided on the possible applications in medicine of network analysis, a modern analysis technique that allows the quantitative study of complex systems and the interpretation of the interrelationships between variables, and which can be applied to numerous areas of medicine. The basics of setting up and interpreting such analysis in different medical fields will be explained. |
Biomolecular mechanisms of aging and age-related diseases |
4 |
first year |
Intensive 4-hour mini-course in which the latest techniques for evaluating cellular changes related to oxidative stress and epigenetic changes resulting from aging will be demonstrated and discussed, and their main research applications will be described. |
Foods with nutraceutical properties and their effects on health |
4 |
first year |
4-hour intensive mini-course. Recent findings in the field of nutraceutics will be explained, with special emphasis on the role of nutraceuticals in gastric and intestinal protection. |
Innovative therapies in medical and surgical settings |
24 |
third year |
Intensive 4-hour mini-course specific to each curriculum. The most recent and innovative medical and surgical therapeutic approaches proposed by modern medicine in each of the curricular areas will be explained and discussed |
Journal club |
16 |
first year |
Periodic small-group meetings with a mentor (4 hours every 6 months for each curriculum) during which synthesis and critical appraisal of articles from the latest scientific literature in each curricular area is provided. |
Translational animal models in somatic and mental disorders |
8 |
first year |
Two intensive mini-courses of 4 hours each will provide an update and critical analysis on the latest data on the application of animal models in translational medicine in relation to diseases relevant to the different curricula. |
2D and 3D cellular models for precision medicine |
4 |
second year |
Intensive 4-hour mini-course on the applications of 2D and 3D cell cultures in disease prevention and treatment research from the perspective of precision medicine, with reference to diseases relevant to different curricula. |
Gut microbiota/brain axis |
4 |
second year |
Intensive 4-hour mini-course in which the mechanisms underlying the bidirectional influence between the gastro-intestinal system and central nervous system functions will be explained, with special reference to the role of the gut microbiota. |
The effects of uremic toxins in patients with chronic renal failure |
4 |
first year |
Intensive 4-hour mini-course in which the effects and mechanisms of action of uremic toxins will be explained with special reference to the role of sulfur compounds among cardiovascular risk factors and the metabolic and epigenetic effects of folate dysfunction. |
Neurodevelopmental disorders: from childhood to adulthood |
4 |
first year |
Intensive 4-hour mini-course in which the most recent data in the literature on the associations between specific aspects of autism spectrum disorders in childhood and the impairment of specific psychopathological domains in adult subjects with schizophrenia and on the hypothesis advanced by several authors that schizophrenia is a disorder associated with neurodevelopmental alterations will be presented and discussed. |
Medical Statistics Course with R Software |
16 |
first year |
STATISTICAL METHODS FOR REPORTING BIOMEDICAL INFORMATION: |
The genetic basis of complex diseases |
4 |
first year |
Intensive 4-hour mini-course in which the latest knowledge on the complex interrelationships between genetic and environmental factors in the study of so-called complex diseases will be explained and discussed. |
The biopsychosocial model in medical diseases |
4 |
first year |
Intensive 4-hour mini-course in which the holistic approach of modern medicine, according to which disease and health are the result of the complex interaction of biological, psychological and social factors, will be explained and the importance of these factors in the therapeutic management of the patient will be discussed. |
The biomarker concept in medicine |
4 |
second year |
4-hour intensive mini-course. State-of-the-art knowledge in the area of potential disease-specific biomarkers relevant to each curriculum will be explained. Special reference will be made to the identification of risk factors from the perspective of preventive medicine and prognostic and treatment response indices from the perspective of personalized medicine. |
"In silico" and "digital twin" models. |
4 |
first year |
4-hour intensive mini-course. The most advanced technologies for computer simulation and visualization of biological and medical processes and their application with the creation of computer models to predict a huge amount of data that are difficult to measure in the individual patient will be demonstrated |
Cycle of Neurowebinars |
20 |
first year |
Neurowebinars is an inter-university and interdisciplinary, educational and editorial networked initiative, in which distinguished researchers and clinicians are invited from time to time to present an evening seminar in the form of a webinar, open to all those enrolled in doctoral and medical specialization courses at participating universities. The purpose is to foster the dissemination of knowledge in the various branches of clinical and experimental neuroscience and neighboring disciplines, promoting discussion and dialogue between science and other fields of knowledge. Neurowebinars are available offline in the video library that can be accessed by members. |
Other educational activities
Type of activity |
Description of the activity |
Enhancement and dissemination of results, intellectual property, and open access to research data and products |
Open Science: basic principles |
Seminars |
The intensive seminar in scientific writing aims to familiarize on the structure and writing of scientific articles by highlighting how, regardless of the specific scientific discipline, scientific publications show common characters and a common writing strategy. the following aspects will be covered. Expected |
Research and knowledge management of European and international research systems |
Funding instruments, research management and procedures: the joint course for the Doctoral School organized by the University includes seminars aimed at presenting the different types of national and international research projects (Horizon, Life, Prin, etc.), structural funds (ERDF, EMFF, EAFRD, etc.), national clusters, regional clusters, reading and interpreting a call for proposals, co-funding, illustrating experiences of approved and funded programs, and acquiring an updated methodology aimed at writing new research proposals with the respective funding systems. |
Enhancement and dissemination of results, intellectual property, and open access to research data and products |
Research Spin Offs and Start-ups: introductory concepts and prerequisites for start-ups; business model and regulations; innovation ecosystem supporting start-ups. There are 3 modules of 4 hours, common to all doctoral programs. The course common to the Ph.D. School focuses on patenting principles, practices and strategies in the processes of managing and exploiting research activity nationally and internationally. The lectures aim to transfer a theoretical background on which to graft tools of practical use, such as: forms and procedural steps for structuring patent applications; techniques for searching patent databases and classification codes; and requirements for patentability of an invention. |
Computer enhancement |
Machine Learning and Neural Networks course common to the Doctoral School of Life Sciences. |
Language improvement |
The course in English is aimed at acquiring the fundamental skills for writing and publishing scientific articles in English, as well as the language skills needed during interactive participation in international academic contexts (conferences, seminars, etc.). |
Research and knowledge management of European and international research systems |
Organized courses common to all PhD students organized in collaboration with the Agency for the Promotion of European Research (APRE) by the Athenaeum: 1) Open access & science, there is 1 module of 2 hours; 2) Dissemination, Communication & Exploitation: how to maximize results, there is 1 module of 2 hours; 3) Possible post PhD training paths, there is 1 module of 2 hours. |
Seminars |
Research evaluation: bibliometric indicators (IF, citation index and H-index). The web and medicine: tools and resources 2.0. Comparison of Pubmed and other databases. Major databases for the biomedical field and on research tools will be analyzed. PhD students will be introduced to the services of the University library |
Basic principles of ethics, gender equality and integrity |
The University, in collaboration with the Agency for the Promotion of European Research (APRE), organizes information tracks on Horizon Europe calls. There are modules on Ethics in Horizon and Europe Gender in Horizon Europe. Ph.D. and Ph.D. students will be stimulated to reflect on the (gender) orientation of research and the role in European funding programs. There are two 4-hour modules (total 8 hours) common to all PhDs. |
Seminars |
"Big data" and national and international databases: cloud computing and parallel computing. There is a common 4-hour module on introductory concepts and a curriculum-specific 4-hour module (for the specificity of databases available or to be created) |
Laboratory activities |
Laboratory and applied research activities are planned for learning basic methodologies and laboratory techniques specific to the different curricula. These include the following areas: biochemistry, molecular biology, genetics, imaging (electrophysiology, structural and functional nuclear magnetic resonance), neuropsychology, and cell culture. |
Employment opportunities for those who complete the PhD program
The PhD in Clinical and Experimental Medical Sciences responds to the growing demand for highly qualified research personnel from centers operating in both public and private institutions, as well as from the pharmaceutical industry. The Ph.D. program appears to be the preferred channel for training new university teaching staff in the related scientific-disciplinary fields. In addition, the training of highly qualified professionals with a multidisciplinary background and specific skills in the analysis of complex data (e.g., with artificial intelligence and machine learning methodologies), capable of responding to the current needs of planning, monitoring, evaluation, and training in the field of health and of transferring the most up-to-date knowledge into intervention programs in the field of prevention, treatment and rehabilitation, could allow the inclusion of future PhDs within the National Health Service, with roles of managerial responsibility or coordination of interdisciplinary areas of applied research.
Active collaboration with local industries engaged in research, has resulted in 8 PON-RI 2014-2020 grants, 3 for Innovation and 5 for Green, in the 37th cycle, on the topics of Smart and Sustainable Industry, Energy and Environment; Health, Food, Quality of Life, consistent with the National Strategies of Intelligent Specialization and the National Research Plan, strengthening the design of highly innovative doctoral training paths. This collaboration is intended to train researchers who can contribute to the development of new ideas for business on the current challenges of the National Plan for Recovery and Resilience, opening up opportunities for employment in industry, particularly pharmaceuticals, nutraceuticals and those operating in the health sector more generally (e.g., in the development of innovative and environmentally friendly biomedical equipment).
Finally, the progressive process of national and European integration will open new spaces for the inclusion of researchers with university training consistent with the educational objectives of the Ph.D. in high-profile basic and clinical research settings.