IT | EN
Coordinator: Prof. Andrea Fiorillo e-mail: Questo indirizzo email è protetto dagli spambots. È necessario abilitare JavaScript per vederlo.
PhD School: Life Sciences
Administrative seat: Department of Mental and Physical Health and Preventive medicine
Contact for information: Dr. Carmela Maddaloni Tel +39 081 5667710/6506 - Fax +30 081 5666523 e-mail: Questo indirizzo email è protetto dagli spambots. È necessario abilitare JavaScript per vederlo.
Duration: 3 years
Involved academic sectors: BIO/10 - BIO/11 - BIO/13 - BIO/16 - FIS/07 - ING-INF/06 - MED/01 - MED/06 - MED/08 - MED/09 - MED/12 - MED/14 - MED/17 - MED/18 - MED/19 - MED/21 - MED/24 - MED/25 - MED/26 - MED/34 - MED/37 - MED/39 - MED/41 - MED/42 - MED/43 - MED/48
Admission procedures
- Assessment of qualifications
- Oral examination
- English language test
- Presentation of a research project
Admission procedures for foreign graduate students:
- Assessment of qualifications
- Oral examination
- English language test
- Presentation of a research project
PhD curricula pertaining the PhD course:
- Curriculum 1: Nephrology
- Curriculum 2: Gastroenterology, Nutrition and healthy eating
- Curriculum 3: Internal medicine, Geriatrics
- Curriculum 4: Neurology
- Curriculum 5: Child psychiatry
- Curriculum 6: Psychiatry
You can submit the application form for the admission to the PhD courses – 38th cycle – starting from June 15, 2022 at 2.00 p.m. (Italian time) of and no later than July 15, 2022 at 2.00 p.m. (Italian time), go to the call link
Description of the training project
The Ph.D. in Clinical and Experimental Medical Sciences offers a training course in research activities based on the development of approaches that are bot interdisciplinary – from preclinical to clinical sciences – and intersectoral – by including alongside the skills of the academic sector, those of the productive one.
In particular, the PhD promotes the aggregation of academic sectors of different areas/disciplines as well as the activation of industrial doctoral courses with research topics consistent with the National Plans for Research and the National Strategy of Intelligent Specialization.
The course provides all the required skills to carry out cutting-edge research on the pathophysiology of somatic and mental diseases with a high impact on public health and the development of innovative biotechnologies and treatments in medicine and surgery.
The integration of preclinical and clinical aspects in the biomedical area, together with the personalization of care, represent core topics common to all the activated curricula, coherently aggregating different disciplines and methodologies, relevant to disciplinary sectors falling within different areas of the ERC Domain "LS- Life Sciences ", including different ERC sectors, in the areas between LS1 and LS7.
The result of the integration of these areas are highly multidisciplinary and multisectoral research projects in emerging fields such as neuroscience, personalized and regenerative medicine, and applied biomedical sciences. The training program promotes a multidisciplinary approach, integrating epidemiology, genetics, anatomical pathology, molecular biology, pathophysiology, diagnostic imaging, research on animal models (in vivo and ex vivo), cell models, and digital models, to identify biomarkers of complex diseases for early diagnosis or course prediction, as well as the development of innovative treatments.
Particular emphasis is given in training researchers to be able to facing the challenges of innovation and digitization, i.e. capable of strategic vision on the emergence of new opportunities, which represent the future of biomedical research, such as the creation, management, and use of "data repository", the use of artificial intelligence and "machine learning" methods that are best suited to the analysis of complex and integrated data (epidemiological, clinical, omics, genetics, socio-health and environmental) or construction of "Knowledge graphs". This type of training and research addresses many of the PNRR challenges in health, from the prevention of chronicity and multiple comorbidities to the development of innovative medical-surgical therapies, to precision medicine.
In the different Curricula, the common innovative approach to research includes 1) the identification of biomarkers useful in the preclinical phase or in the early stages of the disease, in order to set individualized prevention or treatment strategies to improve outcome and quality of life of the patient; 2) the use of animal and cellular models of diseases for the identification of new cellular and molecular targets for the development of innovative drug treatments; 3) the use of computational techniques to create predictive and diagnostic models of various pathologies or innovative "Knowledge Graphs".
The Ph.D. program promotes the active involvement of Ph.D. students in interdisciplinary research projects, their interaction with other researchers and with companies involved in biomedical research, both at national and international levels, in order to create networks of excellence for research and to support the career development of PhD students.
Educational objectives
The PhD in Clinical and Experimental Medical Sciences intends to enhance the synergies between basic research and applied research in medicine and to promote multidisciplinary activities that foster the integration of specialized skills in accordance with a bio-psycho-social approach to prevention and treatment of complex diseases. The PhD program aims to train highly qualified professionals to capably independently apply the most advanced methodologies of basic and clinical research in an interdisciplinary and intersectorial perspective. The goal is to provide a solid theoretical and methodological preparation on the main orientations of biomedical research and to foster the development of highly qualified skills using the most advanced experimental methodologies which enable the planning and the realization of research projects in different areas of medicine; the development of innovative diagnostic and therapeutic applications; the transfer of knowledge to the clinical-therapeutic field according to the principles of Evidence Based Medicine. The PhD course is divided into different curricula related to Psychiatry, Child Neuropsychiatry, Nephrology, Neurology, Geriatrics and Gastroenterology. The training is based on the most recent methodological acquisitions of biomedical research and mainly on the direct participation in research activities, led by internationally renowned tutors and supervisors, with the direct involvement of the PhD student in the implementation of research programs at the proposing institution or at other national or international centers.
Training activities
Planned courses
Course |
Number of hours |
Years in which the course is active |
Description |
Brain imaging techniques: clinical and research applications |
4 |
first anno |
Intensive mini-course corso lasting 4 hours. The most innovative functional and structural neuroimaging techniques will be illustrated, as well as their clinical and research applications in neurology and psychiatry. In particular, the course will address the following topics: 1) advanced applications in the study of principal neurological illnesses in relation to phenotypes and stage of illness; 2) the study of neurofunctional correlates of different domains of severe psychiatric disorders, also relevant to cerebral connectivity. |
Medical statistics – guide to the approach and interpretation of Network Analysis |
4 |
First year |
Intensive mini-course lasting 4 hours in which the basis will be provided on possible applications in medicin of network analysis, a new technique of analysis allowing the quantitative study of complex systems and the interpretation of interrelationship between variables, applicable to several medical fields. The approach and the interpretations of this analysis in several medical field will be illustrated. |
Bio-molecular mechanisms of ageing and of ageing-related diseases |
4 |
First year |
Intensive mini-course lasting 4 hours. It will include the description of the more recent techniques to assess cells modifications related to oxidative stress and to epigenetic modifications related to ageing and their main research applications. |
Nutraceuticals and their impact on health |
4 |
First year |
Intensive mini-course lasting 4 hours. The most recent findings on nutraceuticals will be illustrated, with particular reference to the role of nutraceuticals in gastrointestinal diseases. |
Innovative therapies in medicine and surgery |
24 |
Third year |
Intensive mini-course lasting 4 hours, specific for each curriculum. The most recent and innovative therapeutic approach in medicine and surgery will be illustrated and discusses relevant to each curriculum. |
Journal club |
16 |
First and second years |
Periodic meetings in small groups with a tutor (4 hours every 6 months for each curriculum). During the meetings, a critical evaluation will be conducted of recent articles in the scientific literature for each curriculum. |
Translational animal models in physical and mental diseases |
8 |
First and second years |
Two intensive mini-courses lasting 4 hours each. An update and a critical analysis will be provided on most recent findings on the applications of of animal models in translational medicine relevant to the diseases pertaining the different curricula. |
2D and 3D cell models for precision medicine |
4 |
Second year |
Intensive mini-course lasting 4 hours on the applications of 2D and 3D cultures in the research on prevention and treatment of diseases with a view on precision medicine, relevant to the diseases pertaining the different curricula. |
Gut-microbiota-brain axis |
4 |
Second year |
Intensive mini-course lasting 4 hours. The underlying
mechanisms of the bi-directional influence between gastrointestinal system and central nervous system, with particula reference to the role of gut microbiota. |
The effects of uremic toxins in patients with chronic renal failure |
4 |
First year |
Intensive mini-course lasting 4 hours. The effects and the mechanisms of action ot uremic toxins will be illustrated, with particular reference to the role of sulphur compounds among cardiovascular risk factors and to the metabolic and epigenetic effects of the folate dysfunctions. |
Neurodevelopmental disorders: from childhood to adulthood |
4 |
First year |
Intensive mini-course lasting 4 hours. It will include the description and discussion of the most recent findings on the association between specific aspects of autistic spectrum disorders in childhood and the impairment of specific psychopathological domains in adult subjects with schizophrenia and on the proposed hypothesis that schizophrenia is a neurodevelopmental disorder. |
PhD Course of Medical Statistics with R software |
16 |
First and second years |
Statistical methods to report biomedical information: How and what information to collect Statistical variables (qualitative, quantitative) Main errors in measurement: the related concepts of precision and accuracy Main approaches for data quality control Presentation of data: tables and graphs Data synthesis: main descriptive summary measures Concepts of population, sample and statistical units Main statistical methods to infer conclusions from research findings Probability and probability distributions The Sampling distributions The concepts of parameter and estimate The principles of statistical inference confidence intervals Hypothesis tests type I and type II errors Criteria for choosing the appropriate statistical test The philosophy of the r software: Basic syntax and data structures Import and data management Summary statistics and graphs Statistical inference with R |
The genetic basis of complex diseases |
4 |
First and second years |
Intensive mini-course lasting 4 hours. The most recent findings will di presented and discussed on the complex interrelationships between genetic and environmental factors in the study of the so-called complex diseases. |
The biopsychosocial model in medical diseases |
4 |
First and second years |
Intensive mini-course lasting 4 hours. It will include the presentation of the holistic approach of modern medicine according to which health and disease are the result of a complex interaction between biological, psychological and social factors. The improtance of these factors in the therapeutic management of the patients will be discussed. |
The concept of biomarker in medicine |
4 |
Second year |
Intensive mini-course lasting 4 hours. It will include the presentation of the most recent findings in the field of potential biomarkers specific for diseases pertaining each curriculum, with particular reference to the identification of risk factors in the view of preventive medicine and of prognostic indices in the view of personalized medicine. |
"In silico" and "digital twin" models |
4 |
First and second year |
Intensive mini-course lasting 4 hours. It will include the presentation of the most advanced techniques of computerized simulation and visualization of biological and medical proceses through the creation of computerized models allowing to predict a huge amount of data that are difficult to be measured in a single patient. |
Neurowebinars |
20 |
First, second and third years |
Neurowebinars an inter-university and inter-disciplinary initiative on the net. Distinguished researchers and clinicians are invited to present, in a webinar, an evening seminar, open to all PhD and Trainee students of the participating Universities. The aim is to promote the dissemination of knowledge in different fields of clinical and experimental neurosciences as well as neighbouring disciplines, and to promote the discussion between science and other fields of knowledge. The neurowebinars are available offline in the videolibrary for subscribers. |
Other training activities
Type of activity |
Description of the activity |
Dissemination and exploitation of findings, of intellectual property and of open acces to data and research products |
Open Science: basic principles Preprints, scientific journals, editorial platforms, predatory publishers. FAIR data: Acquired skills: At the end of the course the PhD student will have gained basic digital skills on what Open Science is, on ethic management of data and publications, on production, validation, accessibility of publications and data, on tools for searching open data and publications. Students will be able to: focus information needs, search data and information in digital environments, to access and to navigate within them; to create and to update personal search strategies; to manage digital data, information and contents. The PhD Student, also in the light of ethical and safety aspects, will have received a training on the following contents: correct data management – collection, documentation and storage – data storage or destruction; data conformity to the requirements of the European Commission and to the Open Science policies (FAIR: (FAIR: Findable, Accessible, Interoperable, Reusable). |
Seminars |
The intensive seminare in scientific writing is aimed to get familiar on structuring and drafting scientific papers showing how, regardless of the specific discipline, scientific publications have common aspects and a common writing strategy. The follwing topics will dbe addressed: Contents: description of what does it mean scientific publication, scientific method, curiosity-based or problem-solving based research; peer review process, role of the editor of the scientific journal, description and comparison of different types of scientific journals, impact factor, green, gold e diamond open access; preparation of title and abstract; affiliations and author list, crieria to chose co-authors; drafting of introduction, key steps towards results presentation; results and discussion, order and criterion; the importance of preparation of figures and tables; conclusions and future perspectives; preparation of references; perparation of the cover letter; preparation of poster and oral presentation. |
Research management and knowledge of European and international research systems |
Funding tools, research management and procedures: the common course for PhD organized by the University includes seminars aimed at presenting different types of national and internazional research projects (Horizon, Life, Prin, etc.), structural funds (FESR, FEAMP, FEASR, etc.), national clusters, regional clusters, reading and interpretation of a call, cofinancing, presentation of experiences of approved and funded programs, acquisition of an updated methodology aimed to prepare new research proposals with relevant funding systems. |
Dissemination and exploitation of findings, of intellectual property and of open acces to data and research products |
Spin Off and Start up of research: basic concepts and starting points for the creation of a company; the business model and regulations; the innovation ecosystem to support sturt-up. Tthree modules of 4 hours each are included, common to all PhDs. The cours eis focused on principles, policy and strategies of patenting in management and exploitation processes of national and international research activities. |
Advancement in computer technology |
Machine Learning and neural network course, common to the PhD school Life Sciences. Introduction to Machine Learning and artificial intelligence. - Nearest neighbor. - Multilayer Perceptron (MLP). |
Language advancement |
The English course is aimed at acquiring basic competencies for writing and publishing of scientific papers in English, as well as language skills necessaries during active participation in international academic contexts (congresses, seminars, etc.). |
Research management and knowledge of European and international research systems |
Courses common to all PhD courses will be organized by the University in collaboration with the Agenzia per la Promozione della Ricerca Europea (APRE) of the University: 1) Open access & science, 1 module of 2 hours; 2) Dissemination, Communication & Exploitation: how to maximize results , 1 module of 2 hours; 3) Possible training pathways post-PhD, 1 module of 2 hours. |
Seminars |
The evaluation of research: bibliometric indicators (IF, citation index and H-index). The web and the medicine: tools and resources 2.0. Compariosn between Pubmed and other databases. The major databases relevant to the bibliometric sector and search tools. Resources services of the University library will be showed to the PhD students Training to the use of Scival and Research Professional. |
Basic principles of ethics, gender equality and integrity |
The University, in collaboration with the Agenzia per la Promozione della Ricerca Europea (APRE), organizes trainings on Horizon Europe calls. They include modules on Ethics in Horizon and Europe Gender in Horizon Europe. |
Seminars |
"Big data" and national and international databases: cloud computing and parallel computing. It includes a common module of 4 hours on basic concepts and one of 4 hours specific for each curriculum (addressing the specificity of available or to be created databases). |
Lab activities |
Lab activities and applied research aimed at learning basic methods and lab techniques specific of different curricula. They include the following sectors: biochemistry, molecular biology, genetics, imaging (electrophysiology, structural and functional magnetic resonance imaging), neuropsychology, cell cultures. |
Employment opportunities
The PhD in Clinical and Experimental Medical Sciences responds to the growing demand from centers operating in both public and private institutions, as well as in the pharmaceutical industry for highly qualified research personnel.
The PhD program appears to be the preferred channel for the training of new university teaching staff in the related scientific-disciplinary sectors.
Furthermore, the training of highly qualified professionals with a multidisciplinary preparation and specific expertise in complex data analysis (e.g., with artificial intelligence and machine learning methodologies) to capably respond to the current needs of planning, monitoring, evaluation, training in the field of health, and to transfer the most up-to-date knowledge in intervention programs in the field of prevention, care and rehabilitation, could allow the insertion of future PhDs within the National and International Health Service, with roles of managerial responsibility or coordination of interdisciplinary areas of applied research.
The active collaboration with local industries involved in research, allowed us to achieve 8 PON-RI 2014-2020 scholarships, 3 for Innovation and 5 for Green, within the 37° PhD cycle, about intelligent and sustainable Industry, energy and environment; Health, Nutrition, Quality of Life, coherent with the National Strategies of Intelligent Specialization and the Research National Plan, enhancing the planning of highly innovative PhD training. This collaboration aims to train researchers able to contributing to the development of new ideas for the current challenges of National Plan for Recovery and Resilience, opening up possibilities of employment in the industry, in particular in pharmaceutical and nutraceutical one, and more in general in the healthcare industry (e.g., in the development of innovative and ecological biomedical devices).
Finally, the progressive national and international integration process will open new opportunities for the inclusion of researchers with university education coherent with the training objectives of the PhD, in high basic and clinical research contexts.